Integrated Precision Medicine Technologies
Research Center of Excellence

Position: Bioinformatics & Systems Medicine
Affiliation: The Cyprus Institute of Neurology and Genetics
Email: georges@cing.ac.cy

Dr. George Spyrou (male) is the Bioinformatics ERA Chair Holder and the Head of the Bioinformatics Group at CING.  He holds a BSc on Physics, an MSc on Medical Physics and an MSc on Bioinformatics as well. During his PhD he worked on algorithms and simulations focusing on breast cancer imaging. In 1994 he joined the Medical Imaging Research Group at the Physics Department of University of Athens as Research Associate, in 1998 he was selected to work at the Informatics Research Office of the Academy of Athens on a medical image analysis and decision support project concerning the early diagnosis of breast cancer. In 2001, he joined the Biomedical Research Foundation of the Academy of Athens (BRFAA) at its very beginning, being appointed as a Research Scientist of level B. Since 2001 and for over 10 years he worked on the strategic plan and implementation of IT development at BRFAA, acting as the Head of the Department of Informatics and New Technologies of BRFAA. Among his tasks was to design, organize and supervise from scratch the whole Information Technology infrastructure of the Institute. In parallel, he was organizing his research group and was running his own research on bioinformatics and medical informatics. In 2007 Dr. Spyrou was promoted to Senior Research Scientist (Level A) at BRFAA after successful evaluation.  Since 2009 he is teaching a full semester course in the Postgraduate Program “Information Technologies in Medicine and Biology” at the University of Athens.  He is also a visiting instructor on Systems Bioinformatics and Network Analysis in other two postgraduate courses, namely the Master program on “Complex Systems and Networks” at the Aristotle University of Thessaloniki and the Master program on “Translational Research in Molecular Biology and Genetics” at the Democritus University of Thrace. Through his teaching activities Dr. Spyrou has the opportunity of supervising/mentoring a number of MSc and PhD students. His work includes computational methods that act as bridges between molecular biology, systems biology and molecular medicine, exploiting computational intelligence and high performance computing for multi-omics network analysis, systems bioinformatics and in silico drug discovery. Up to now, he has served as Reviewer, Invited Speaker, Chairman and Scientific Advisory Board Member in topics related to Biomedical Informatics topics while he has authored over 130 scientific publications in peer reviewed journals and international conference proceedings. Dr. Spyrou is the Bioinformatics ERA Chair Holder and the Head of the Bioinformatics Group at the Cyprus Institute of Neurology and Genetics.

Bioinformatics Group

The Bioinformatics Group has been recently established at CING headed by the Bioinformatics ERA Chair. Its research is focusing on Computational Diagnostics and Therapeutics inside the fields of Systems Bioinformatics and Medical Informatics. The Group exploits network-based bioinformatics methodologies along the axis of translational research to develop tailor-made applications of computer aided diagnosis and risk estimation regarding diseases of interest at CING. Also, the Group utilizes any kind of biomedical data available (from omics to imaging and other clinical data) to reconstruct and analyze multi-layered networks towards integromics and personalized medicine. Among the major Group’s research interests are the following: Network Analysis and networked biomarker discovery, Machine learning for computer aided diagnosis, Modeling and Simulation of Complex Biological Networks, Multi source and multilayer analysis towards precision medicine, In silico drug discovery and drug repurposing, Post-omic analysis and knowledge extraction, e-Health, m-Health and Assistive technologies informatics.

Department of Neurogenetics

The Neurogenetics Department occupies dedicated spaces of 100m2 for offices and laboratories. Furthermore, the Neurogenetics Department has access to core molecular genetics laboratory space and equipment that includes a NextSeq500, an AB 3130XL automatic analyzer, an ABI 7900 Real time PCR machine and a fully equipped tissue culture room.

Electron Microscopy/Molecular Pathology

The laboratory facilities of the Electron Microscopy/Molecular Pathology include; Laser Capture Microdissection (LCM) (Veritas LCC1704), confocal microscope, ZEISS brightfield and fluorescent microscope, Automated DNA sequencer – (ABI PRISM 310), dHPLC DNA fragment analysis (Transgenomics), Fast Real-time PCR system (ABI 7900 HT), genetic analysers 3130XL x3, Beckman analyzers x3, PCR Thermal Cyclers, Centrifuges (some with temperature control), SDS-PAGE & Western blotting Equipment, Dedicated Tissue culture Facility (with laminar flow hood and incubator) and Chemical hoods. In addition, the department hosts a newly established proteomics facility which consists of liquid chromatography systems (Waters nanoAcquity UPLC with 2D and Waters Acquity I-Class), a triple Quad MS system (Waters Xavo TQD) and a high resolution ion mobility mass spectrometry system (Waters Synapt G2Si) as well as an isoelectric focusing (IEF) system (Agilent 3100 OFFGEL fractionator).

Clinical Facilities

Clinical facilities include, in addition to the Outpatient Department, and the Neurology Ward, a laboratory of Clinical Neurophysiology and the laboratory of Neuropathology. The Transgenic Mouse Facility (TMF) is a core facility of the CING and is located in the basement of the CING building. The 5 CING Neurology Clinics are: Neurology Clinic A is predominantly involved with the clinical and laboratory evaluation (muscle and nerve biopsies) of patients with an emphasis on neuromuscular disorders such as, myopathies, motor neuron disease and neuropathies. The Clinic also has an interest in multiple sclerosis, neurodegenerative and neurogenetic disorders. Since 2002, a Familial Amyloidosis neuropathy clinic takes place once a month where a multidisciplinary service is offered. Neurology Clinic B provides tertiary medical care to patients with neurological disorders and other neurogenetic and genetic illnesses (epilepsy, sleep disorders, movement disorders, Alzheimer's disease, and other neurodegenerative disorders as well as behavioral problems that result from brain disease) that require specialized diagnosis and treatment. Neurology Clinic C is a Neurovascular laboratory which offers services in the field of Neurosonology. Colour coded duplex-doppler studies of the extracranial carotid arteries, the extracranial vertebral arteries and the intracranial arteries (both the anterior and the posterior circulations) are performed on a regular service basis. Neurology Clinic D is the Electromyography (EMG) Laboratory which specializes in electrodiagnostic examinations that evaluate, monitor, diagnose, and exclude disorders of the peripheral nervous system. Unlike imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT), electrophysiological measures from peripheral nerves and/or muscles bestow information about their function. As electrodiagnostic studies are an extension of the patient’s clinical history and physical examination, each test session is designed and interpreted in parallel with that information. Consequently, our team is able to provide high-level patient care and diagnostic support to referring physicians and patients. Neurology Clinic E provides tertiary medical care to patients with various neurological disorders, focusing on neuromuscular (myasthenia gravis, peripheral neuropathies and myopathies, motor neuron disease), neurogenetic and other degenerative, autoimmune and demyelinating disorders of the peripheral and central nervous system. The Clinic also participates in the provision of specialized electrodiagnostic services (electromyography and nerve conduction studies) in the EMG lab. Clinic E includes the Neuroscience Laboratory mainly involved in translational neurological research, as well as the CING Mouse Facility, which serves as national core faciltiy providing services to researchers from CING and other institutions.

The Cyprus Institute of Neurology and Genetics Team

Eleni Zampa

Eleni Zampa

Neurodegenerative Disorders

The Cyprus Institute of Neurology and Genetics

Savvas Papacostas

Savvas Papacostas

Neurodegenerative Disorders

The Cyprus Institute of Neurology and Genetics

Marios Pantziaris

Marios Pantziaris

Neurodegenerative Disorders

The Cyprus Institute of Neurology and Genetics

Yiolanda Christou

Yiolanda Christou

Neurodegenerative Disorders

The Cyprus Institute of Neurology and Genetics

Christiana Demetriou

Christiana Demetriou

Neurodegenerative Disorders

The Cyprus Institute of Neurology and Genetics

Eleni Leonidou

Eleni Leonidou

Neurodegenerative Disorders

The Cyprus Institute of Neurology and Genetics

Ioanna Kousiappa

Ioanna Kousiappa

Neurodegenerative Disorders

The Cyprus Institute of Neurology and Genetics

Kyriacos Kyriacou

Kyriacos Kyriacou

Cancer

The Cyprus Institute of Neurology and Genetics

Andreas Hadjisavvas

Andreas Hadjisavvas

Cancer

The Cyprus Institute of Neurology and Genetics

Kyriaki Michaelidou

Kyriaki Michaelidou

Cancer

The Cyprus Institute of Neurology and Genetics

Maria Loizidou

Maria Loizidou

Cancer

The Cyprus Institute of Neurology and Genetics

Kyproulla Christodoulou

Kyproulla Christodoulou

Molecular/ Cellular Biosciences (translational –Omics)

The Cyprus Institute of Neurology and Genetics

Paschalis Nicolaou

Paschalis Nicolaou

Molecular/ Cellular Biosciences (translational –Omics)

The Cyprus Institute of Neurology and Genetics

Christina Votsi

Christina Votsi

Molecular/ Cellular Biosciences (translational –Omics)

The Cyprus Institute of Neurology and Genetics

Antonis Ververis

Antonis Ververis

Molecular/ Cellular Biosciences (translational –Omics)

The Cyprus Institute of Neurology and Genetics

George Spyrou

George Spyrou

Bioinformatics & Systems Medicine

The Cyprus Institute of Neurology and Genetics

Anastasios Oulas

Anastasios Oulas

Bioinformatics & Systems Medicine

The Cyprus Institute of Neurology and Genetics

Margarita Zachariou

Margarita Zachariou

Bioinformatics & Systems Medicine

The Cyprus Institute of Neurology and Genetics

George Minadakis

George Minadakis

Bioinformatics & Systems Medicine

The Cyprus Institute of Neurology and Genetics

Kleitos Socratous

Kleitos Socratous

Cancer

The Cyprus Institute of Neurology and Genetics