Integrated Precision Medicine Technologies
Research Center of Excellence

Position: Medical Imaging & Biosignal Analysis
Affiliation: Republic of Cyprus, Ministry of Health

IsabelleChrysanthou

Dr. Isabelle Chrysanthou-Baustert is a Medical Physicist of the Medical Physics Department at Nicosia General Hospital. She holds a physics degree from the Swiss Federal Institute of Technology (ETHZ), an MSc in Radiation Physics, a PGCert in Healthcare Education and a PhD in Medical Physics (the Institute of Cancer Research and the Royal Marsden) from the University of London. She has over 18 years of experience in the field of medical physics ranging from clinical work in radiotherapy and diagnostic radiology, over academic work (research, teaching) and business development to regulatory work for the government. She founded and managed a high tech start-up on medical imaging for which she won the first prize at the Cyprus Entrepreneurship Competition and raised ¼ million Euros. Recently, she held the post of vice-chair at the Council of the European Union in Brussels for the regulatory work in the area of medical devices. She has focused on research on the optimisation of medical imaging techniques to improve diagnosis twice in her career: once on MRI and more recently in Nuclear Medicine. Her peer reviewed research has been published in Journals like Physics in Medicine and Biology, Magnetic Resonance Imaging and the Journal of Nuclear Cardiology. Her early work on Magnetic Resonance Imaging received over 350 citations and her recent work in Nuclear Medicine was featured in the editorial of the journal issue.

Department of Intensive Care Medicine (DICM)

The Department of Intensive Care Medicine (DCIM) at the Nicosia General Hospital (www.intensivecare.com.cy/index.php/en/) will be a leading participant in the PMT CoE project. Opened along with the new Nicosia General Hospital in Oct 2006, the largest and only tertiary referral Hospital in Cyprus (550 acute beds), DICM has employed the first “closed type” – Intensivists stuffed ICU and is presently the largest Intensive Care facility in the island (17 beds ICU – 6 beds HDU – 4 beds Burns ICU – 12 beds CCU = total of 39 critical care beds). It employs 7 full time – board certified Intensivists (multidisciplinary access), 6 full time Intensive Care fellows in training (board certified in a primary specialty), more than 130 nurses in the critical areas and a multidisciplinary team of allied health professionals. DICM is admitting more than 1000 critically ill patients / year and main ICU (17 beds, ≈750 patients per year) has a crude mortality of 21% and a standardized mortality ratio (SMR) of 0.92 in 2015 (external audit data from PROSAFE system).Since its opening in 2006, DICM as an entity and/or through its scientific personnel has participated in over 15 R&D projects co-funded by national as well as EU (INTERREG, FP6, FP7, EUMEDIS, Leonardo etc.)

Oncology Department

Nicosia General Hospital (NGH) is a 500-bed, public, tertiary hospital with teaching function in the capital of Cyprus. It offers high-quality medical services in a wide range of specialties and is affiliated with several state and private academic institutions, including the University of Cyprus Medical School, the Cyprus Technology University Nursing Department and Saint George University of London. The Oncology Department of NGH was the first medical centre on the island dedicated to cancer care services, including external beam radiotherapy, brachytherapy, systemic anticancer therapies and palliative care. It was relocated to the new NGH building in 2006, and currently operates as a fully organized Medical Oncology Clinic with more than 800 admissions per year. The NGH Oncology Department consists of an 18-bed inpatient ward, a chemotherapy day care unit and an outpatient clinics, it offers a 24-hour oncology emergency coverage and it closely collaborates with patient advocacy associations offering homecare nursing, hospice and psychology support services. The Department treats all types of solid tumours in a multidisciplinary team approach integrating a wide range of medical, surgical, radiological and laboratory specialties affiliated with the Hospital, as well as the radiation oncology services of collaborating healthcare providers, including the Bank of Cyprus Oncology Centre and the German Oncology Centre. The medical staff has expertise in the use of all currently available types of anticancer treatments, including cytotoxic chemotherapy, immunotherapy, hormone and molecular targeted therapies.

Neurosurgery Department

The Nicosia General Hospital neurosurgical clinic is the only state neurosurgical clinic in Cyprus. It is staffed with seven consultant neurosurgeons, which constitutes the biggest neurosurgical team in the island. As a result, we evaluate, operate and follow up the majority of intracranial tumors in the country. During last year we operated on 570 patients with various neurosurgical issues. Of these, approximately 70 were patients with intracranial tumors, while 30 of these cases concerned glioblastoma patients. 170 patients were operated on an emergency basis due to central nervous system trauma. This annual flow of patients makes our clinic a very significant neurosurgical center referral in Cyprus.

Histopathology Department

The Histopathology Department of Nicosia is the only public pathology laboratory in Cyprus, providing histological diagnosis to more than 80% of the Cypriot population. It employs, ten registered Pathologists and eleven qualified technicians, including a Molecular Biologist and a PhD in Molecular Diagnostics. Two of the Technicians are specially trained to support the Medical personnel in biopsy processing and microscopy. The Department offers specialised services on the entire spectrum of pathology, ranging from neuropathology, bone marrow and lymph node pathology, renal pathology, dermatopathology, forensic pathology etc, that refer to modern diagnostic techniques, such as a constantly updated panel of immunohistochemistry and molecular pathology (FISH, CISH, PCR, RT-PCR, etc) . This environment, provides the State with reliable diagnostic pillars, and serves as the sole Oncology Reference Center with the richest archival material in the state, both for the future diagnostic and prognostic, as well as for research purposes. More particularly, it has a well-organised specimen repository including paraffin blocks and histology slides covering biopsies of the last two decades supported by a comprehensively established electronic data management system. This wealth of biospecimen does not only involve biopsies or surgical samples from all Cyprus-based Public Hospitals but, serving as the State’s Reference Center, the NGH Histopathology Department receives samples from across the Private Sector via the two Government-affiliated Oncology Centers (i.e the Bank of Cyprus Oncology Center and the German Oncology Center) for a mandatory second opinion as well as for specialised diagnostics such as FISH and molecular analysis for immunotherapeutics (i.e. PDL-1). The department employees the WHO revised safety guidelines for diagnostic laboratories and is in the process of the ISO/IEC assessment. The department serves as a teaching affiliate of the UCY Medical School and has been engaged in numerous projects with strategic partners including UCY, CING and EPOS. Both the archival and future bioptic material, would be utilized more effectively for research.

Department of Radiology

The Department of Radiology (DR) of the NGH performs imaging, diagnostics and interventional procedures both on an inpatient and an outpatient basis as well as at the Emergency Department and at rural medical centres. The Department performs more than 130,000 x-rays, 30,000 CTs, 18,000 ultrasounds, 5,000 MRIs and many more procedures. As part of a population screening program more than 17,000 mammographies are performed and read by 3 individual radiologists. The DR employs 11 radiologists and 49 technicians. The Radiological Department of the Nicosia General Hospital is headed by Dr Vayios Partassides and its personnel includes 13 Consultant Radiologists, 5 Specialist Registrar Radiologist in training and 43 Radiology Technologists, 3 nurses and 10 secretaries. The Department performs imaging, diagnostic and interventional examinations of outpatients and inpatients as well as inpatients from the Department of Accidents and Emergency and from Urban and Rural Health Centres. The Department is active in the following tasks: education of the medical students of the University of Cyprus and the University of Nicosia; training of specialist registrar radiologists; radiology technologists training in Radiation Protection in cooperation with the Department of Medical Physics of the Hospital.

Department of Medical Physics

The activities of the Department include the following activities: personal dosimetry services; secondary standard dosimetry calibration; Radiation Imaging Quality Control Services for all public hospitals; quality assurance for non-ionising radiation equipment; licensing advice on radiation protection and radiological safety aspects; development and support of specialist software packages; developing, supervision and implementation of working protocols; participation in tendering and evaluation committees for medical equipment; training; development of the PACS system for all Governmental Hospitals and Health Centres; supervision of the PACS team.

Republic of Cyprus, Ministry of Health Team

Christos Th. Nicolaou

Christos Th. Nicolaou

MOH Team Coordinator

Republic of Cyprus, Ministry of Health

Lakis Palazis

Lakis Palazis

Traumatic Brain Injury

Republic of Cyprus, Ministry of Health

Androula Papastylianou

Androula Papastylianou

Traumatic Brain Injury

Republic of Cyprus, Ministry of Health

Nikolas Stylianides

Nikolas Stylianides

Traumatic Brain Injury

Republic of Cyprus, Ministry of Health

Georgios Ioannidis

Georgios Ioannidis

Cancer

Republic of Cyprus, Ministry of Health

Kostantinos Nikolopoulos

Kostantinos Nikolopoulos

Cancer

Republic of Cyprus, Ministry of Health

Moses-Akis Lambrou

Moses-Akis Lambrou

Cancer

Republic of Cyprus, Ministry of Health

Konstantinos Faropoulos

Konstantinos Faropoulos

Cancer

Republic of Cyprus, Ministry of Health

Constantinos Marinos

Constantinos Marinos

Cancer

Republic of Cyprus, Ministry of Health

Demetris Nicolaides

Demetris Nicolaides

Cancer

Republic of Cyprus, Ministry of Health

Ioanna Zouvani

Ioanna Zouvani

Molecular/ Cellular Biosciences (translational –Omics)

Republic of Cyprus, Ministry of Health

George Georgiou

George Georgiou

Molecular/ Cellular Biosciences (translational –Omics)

Republic of Cyprus, Ministry of Health

Christiana Poullou

Christiana Poullou

Molecular/ Cellular Biosciences (translational –Omics)

Republic of Cyprus, Ministry of Health

Panagiota Kara

Panagiota Kara

Molecular/ Cellular Biosciences (translational –Omics)

Republic of Cyprus, Ministry of Health

Aristi Kourri

Aristi Kourri

Medical Imaging & Biosignal Analysis

Republic of Cyprus, Ministry of Health

Athena G. Skoulariki

Athena G. Skoulariki

Medical Imaging & Biosignal Analysis

Republic of Cyprus, Ministry of Health

Prodromos A Kaplanis

Prodromos A Kaplanis

Medical Imaging & Biosignal Analysis

Republic of Cyprus, Ministry of Health

Charalambos Yiannakkaras

Charalambos Yiannakkaras

Medical Imaging & Biosignal Analysis

Republic of Cyprus, Ministry of Health

Demetris Kaolis

Demetris Kaolis

Medical Imaging & Biosignal Analysis

Republic of Cyprus, Ministry of Health

Isabelle Chrysanthou-Baustert

Isabelle Chrysanthou-Baustert

Medical Imaging & Biosignal Analysis

Republic of Cyprus, Ministry of Health