“It is much more important to know what sort of a patient has a disease than what sort of a disease a patient has.”
William Osler (1849-1919)
Precision medicine is an approach to disease diagnosis, treatment and prevention that seeks to maximize effectiveness by taking into account individual variability in clinical presentation, history, genes, environment, and lifestyle. Precision medicine aspires to redefine our understanding of disease onset and progression, treatment response, and health outcomes through the more precise quantification of the individualized factors that contribute to health and disease. Such an understanding will lead to more accurate diagnoses, more rational disease prevention strategies, better treatment selection, and the development of novel therapies.
Current clinical research paradigm. Research is performed in scientific silos attempting to form a consensus based on cohort responses and one-size-fits-all approaches, often with little feedback between different research blocks
The proposed integrated research paradigm where multifactorial, multimodality, multiscale data are generated and integrated to be investigated by interdisciplinary teams based on feedback from stratified populations